How the Alliance Works
Every breakthrough begins with a question. Can a treatment work better? Can disease be prevented or detected earlier? Can we improve quality of life? For more than 65 years, the Alliance for Clinical Trials in Oncology has been turning questions into clinical research that has fundamentally changed cancer care.

A collaborative structure supporting groundbreaking clinical trials
As part of the National Cancer Institute’s National Clinical Trials Network (NCTN) and NCI Community Oncology Research Program (NCORP), the Alliance brings together 26,000 physicians, researchers, nurses, statisticians, and other healthcare professionals across 112 member institutions and nearly 1,500 affiliated medical centers to transform scientific questions into practice-changing cancer interventions.
Leadership & Administration
Led by a Group Chair and Principal Investigator, Alliance leadership sets direction, provides oversight, and ensures accountability.
Committees
Committees provide scientific direction by setting research priorities, evaluating trial concepts, and guiding the development of studies.
From concept to clinical trial
An overview of how Alliance clinical trials are developed, including NCTN and AFT pathways, from concept through activation.


